Research

We work on state-of-the-art MRI techniques both on clinical (1.5T/3T) and preclinical MRI (11.7 T) scanners

  • to improve the understanding of physiological processes,
  • to develop novel diagnostic MRI techniques,
  • to disclose novel diagnostic MRI biomarkers,
  • to find new targets for therapeutic treatment

in/for cardiovascular diseases.

National and International Collaborators:

Dr. Luisa Ciobanu
NeuroSpin, CEA,
Gif-sur-Yvette, France

Prof. Dr. Gustav Strijkers
Department of Biomedical Engineering and Physics,
Amsterdam UMC,
University of Amsterdam,
Amsterdam, The Netherlands

Prof. Dr. Christof Karmonik
Houston Methodist Research Institute,
Translational Imaging Center,
Houston, Texas, USA

Dr. Hikari Yoshihara
Laboratory for Functional and Metabolic Imaging,
Institute of Physics,
Swiss Federal Institute of Technology Lausanne (EPFL),
Lausanne, Switzerland

Prof. Dr. Lars Linsen
Institute of Computer Science
University Münster
Münster, Germany

Prof. Dr. Ute Neugebauer
Leibniz Institute of Photonic Technology,
Albert-Einstein-Straße 9,
Jena, Germany

Prof. Dr. Marcus Franz
Department of Internal Medicine I,
University Hospital Jena,
Friedrich-Schiller-University Jena,
Jena, Germany

PD Dr. Michael Schwarzer
Department of Cardiothoracic Surgery,
Jena University Hospital,
Friedrich Schiller University Jena,
Jena, Germany

Prof. Dr. José Luis Oliveira / Dr. Eduardo Pinho
BMD Software,
Creative Science Park,
Aveiro, Portugal

Prof. Dr. Xiaoyi Jiang
Institute of Computer Science
University Münster
Münster, Germany

Prof. Dr. Walter Heindel
Clinic for Radiology,
University Hospital Münster,
Münster, Germany

Prof. Dr. Cornelius Faber
Clinic for Radiology,
Translational Research Imaging Center,
University Hospital Münster,
Münster, Germany

Prof. Dr. Stefan Reuter
Department of Medicine D,
Division of General Internal Medicine,
Nephrology and Rheumatology,
University Hospital Münster,
Münster, Germany

Dr. Marc Lehmann / PD Dr. Christoph Enzensperger
SmartDyeLivery GmbH
Philosophenweg 7a
Jena, Germany

Publications

2024

Schache D, Peddi A, Nahardani A, Faber C, Hoerr V. Corrections for Rabi oscillations in cardiac chemical exchange saturation transfer MRI under the influence of very short preparation pulses. NMR Biomed. 2024, 37(4):e5081. doi: 10.1002/nbm.5081

2023

Hoffmann E, Schache D, Höltke C, Soltwisch J, Niland S, Krähling T, Bergander K, Grewer M, Geyer C, Groeneweg L, Eble JA, Vogl T, Roth J, Heindel W, Maus B, Helfen A, Faber C, Wildgruber M, Gerwing M, Hoerr V. Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy. J Transl Med. 2023, 21(1):577. doi: 10.1186/s12967-023-04451-6.

Mandal S, Tannert A, Ebert C, Guliev RR, Ozegowski Y, Carvalho L, Wildemann B, Eiserloh S, Coldewey SM, Löffler B, Bastião Silva L, Hoerr V, Tuchscherr L, Neugebauer U. Insights into S. aureus-Induced Bone Deformation in a Mouse Model of Chronic Osteomyelitis Using Fluorescence and Raman Imaging. Int J Mol Sci. 2023, 24(11):9762. doi: 10.3390/ijms24119762.

Hoffmann E, Gerwing M, Krähling T, Hansen U, Kronenberg K, Masthoff M, Geyer C, Höltke C, Wachsmuth L, Schinner R, Hoerr V, Heindel W, Karst U, Eisenblätter M, Maus B, Helfen A, Faber C, Wildgruber M. Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy. Breast Cancer Res. 2023, 25(1):56. doi: 10.1186/s13058-023-01658-9.

Zhao WT, Herrmann KH, Sibgatulin R, Nahardani A, Krämer M, Heitplatz B, van Marck V, Reuter S, Reichenbach JR, Hoerr V. Perfusion and T2 Relaxation Time as Predictors of Severity and Outcome in Sepsis-Associated Acute Kidney Injury: A Preclinical MRI Study. J Magn Reson Imaging. 2023, 58(6):1954-1963. doi: 10.1002/jmri.28698.

Hoffmann E, Gerwing M, Niland S, Niehoff R, Masthoff M, Geyer C, Wachsmuth L, Wilken E, Höltke C, Heindel WL, Hoerr V, Schinner R, Berger P, Vogl T, Eble JA, Maus B, Helfen A, Wildgruber M, Faber C. Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI. J Immunother Cancer. 2023, 11(3):e006092. doi: 10.1136/jitc-2022-006092.

Rohrbeck M*, Hoerr V*, Piccini I, Greber B, Schulte JS, Hübner S, Jeworutzki E, Theiss C, Matschke V, Stypmann J, Unger A, Ho HT, Disse P, Strutz-Seebohm N, Faber C, Müller F-U, Ludwig S, Rescher U, Wolfgang AL, Klingel K, Busch K, Eisner V, Stefan Peischard *, Guiscard Seebohm*. Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis. MDPI Cells 2023, 12, 550. https://doi.org/10.3390/cells12040550.

2022

Gerwing M, Hoffmann E, Kronenberg K, Hansen U, Masthoff M, Helfen A, Geyer C, Wachsmuth L, Höltke C, Maus B, Hoerr V, Krähling T, Hiddeßen L, Heindel W, Karst U, Kimm MA, Schinner R, Eisenblätter M, Faber C, Wildgruber M. Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer. Front Oncol. 2022,12:1000036. doi: 10.3389/fonc.2022.1000036. eCollection 2022.

Hoerr V, Nahardani A, Rasche V, Chapter 35: Small animal imaging in the book “Motion Correction in MR: Correction of Position, Motion, and Dynamic Field Changes” published by Andre van der Kouwe, Jalal B. Andre

Nahardani A, Krämer M, Ebrahimi M, Herrmann K-H, Leistikow S, Linsen L, Moradi S, Reichenbach JR, Hoerr V. Time-resolved velocity mapping at high magnetic fields: A preclinical comparison between stack-of-stars and cartesian 4D-Flow. Front Phys. 2022, 10:963807. doi: 10.3389/fphy.2022.963807.

Schache D, Bardin S, Ciobanu L, Faber C, Hoerr V. Ultrafast CEST line scanning as a method to quantify mutarotation kinetics. J Magn Reson. 2022, 342:107270. doi:10.1016/j.jmr.2022.107270. Epub 2022 Jul 16. PMID: 35905529.

Miek L, Jordan PM, Günther K, Pace S, Beyer T, Kowalak D, Hoerr V, Löffler B, Tuchscherr L, Serhan CN, Gerstmeier J, Werz O. Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid. Immunology. 2022,166(1):47-67. doi: 10.1111/imm.13449. Epub 2022 Mar 9.

Schwarz C, Buchholz R, Jawad M, Hoesker V, Terwesten-Solé C, Karst U, Linsen L, Vogl T, Hoerr V, Wildgruber M, Faber C. Fingerprints of Element Concentrations in Infective Endocarditis Obtained by Mass Spectrometric Imaging and t-Distributed Stochastic Neighbor Embedding. ACS Infect Dis. 2022,8(2):360-372. doi: 10.1021/acsinfecdis.1c00485. Epub 2022 Jan 19.

2021

Nahardani A, Leistikow S, Grün K, Krämer M, Herrmann KH, Schrepper A, Jung C, Moradi S, Schulze PC, Linsen L, Reichenbach JR, Hoerr V*, Franz M*. *equally contributed

Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI. Diagnostics (Basel). 2021,12(1):58. doi: 10.3390/diagnostics12010058.

Funding

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